The article highlighted in this issue is “Dizocilpine Improves Beneficial Effects of Cholinergic Antagonists in Anticholinester-

between cholinergic and N-methyl-D-aspartate (NMDA) receptors as mediators of anticholinesterase toxicity. The following review summarizes these findings and discusses their broader implica-tions for central nervous system pharmacology. Alzheimer’s dis-ease is discussed as an example of how knowledge of the interac-tions between NMDA and cholinergic receptors may lead to a better understanding of human disease. In the study by Dekundy et al., mice received the anticho-linesterase pesticides dichlorvos or methomyl alone, or follow-ing pretreatment with atropine (a muscarinic-cholinergic an-tagonist), mecamylamine (a nicotinic-cholinergic antagonist), or dizocilpine (an NMDA receptor antagonist also known as MK-801). Consistent with existing literature, dichlorvos and methomyl each induced dose-dependent seizures and lethality in mice. Atropine, a preferred treatment for anticholinesteras